CD14 antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Coreceptor for bacterial lipopolysaccharide(PubMed: 1698311, PubMed: 23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide(LPS)(PubMed: 20133493, PubMed: 23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response(PubMed: 8612135). Acts as a coreceptor for TLR2: TLR6 heterodimer in response to diacylated lipopeptides and for TLR2: TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway(PubMed: 16880211). Immunogen: CD14 molecule Synonyms: CD14, CD14 molecule Observed MW: 50-55 kDa Uniprot ID: P08571 Reactivity: Human Tested Application: ELISA, IHC Recommended dilution: IHC: 1: 20-1: 200 Gene ID: 929 Research Area: Stem Cells, Immunology, Signal Transduction, Cancer