Collagen Type I antibody

Volume: 100 µg Purification: protein A+G purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Mouse Clonality: monoclonal Clone ID: 3D7 Isotype: IgG1 Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.) Background: This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. Immunogen: collagen, type I, alpha 2 Synonyms: Alpha 2 type I collagen, COL1A2, Collagen alpha 2(I) chain, Collagen Type I, collagen, type I, alpha 2, OI4 Observed MW: Uniprot ID: P08123 Reactivity: Human Tested Application: ELISA, IHC Recommended dilution: IHC: 1: 2000 - 1: 8000 Gene ID: 1278 Research Area: Stem Cells, Cardiovascular