Cytokeratin 8 antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.) Background: This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. Immunogen: keratin 8 Synonyms: CARD2, CK 8, CK8, CYK8, Cytokeratin 8, K2C8, K8, keratin 8, KO, KRT8, Type II keratin Kb8 Observed MW: 53 kDa Uniprot ID: P05787 Reactivity: Human, Mouse Tested Application: ELISA, WB, IF, IHC Recommended dilution: WB: 1: 500 - 1: 2000; IHC: 1: 50 - 1: 200; IF: 1: 50 - 1: 200 Gene ID: 3856 Research Area: Stem Cells, Immunology, Developmental biology, Cancer