CREB3L2 antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Transcription factor involved in unfolded protein response(UPR). In the absence of endoplasmic reticulum(ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes(By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death(PubMed: 17178827). In vitro activates transcription of target genes via direct binding to the CRE site(PubMed: 17178827). Immunogen: cAMP responsive element binding protein 3-like 2 Synonyms: BBF2H7 Observed MW: 60-70 kDa Uniprot ID: Q70SY1 Reactivity: Human, Mouse, Rat Tested Application: ELISA, WB Recommended dilution: WB: 1: 500-1: 2000 Gene ID: 64764 Research Area: Metabolism