COPS4 antibody
Volume: 100 µg
Purification: Immunogen affinity purified
Form: liquid
Purity: 95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID:
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background: Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Immunogen: COP9 constitutive photomorphogenic homolog subunit 4(Arabidopsis)
Synonyms: CSN4
Observed MW: 40; 46 kDa
Uniprot ID: Q9BT78
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC, IP
Recommended dilution: WB: 1: 500-1: 2000; IP: 1: 200-1: 1000; IHC: 1: 20-1: 200
Gene ID: 51138
Research Area: Cell Division and Proliferation, Metabolism
This content will be shared across all product pages.
Internal Reference:
FNab01872
Our latest content
Check out what's new in our company !
Your Dynamic Snippet will be displayed here... This message is displayed because you did not provide both a filter and a template to use.