Collagen Type IV antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Type IV collagen is the major structural component of glomerular basement membranes(GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and-9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. Immunogen: collagen, type IV, alpha 2 Synonyms: COL4A2, Collagen alpha 2(IV) chain, Collagen Type IV, collagen, type IV, alpha 2, DKFZp686I14213, FLJ22259 Observed MW: 200 kDa Uniprot ID: P08572 Reactivity: Human, Mouse, Rat Tested Application: ELISA, IHC Recommended dilution: IHC: 1: 20-1: 200 Gene ID: 1284 Research Area: Cancer, Immunology