CNOT7 antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. Immunogen: CCR4-NOT transcription complex, subunit 7 Synonyms: CAF1 Observed MW: 33-35 kDa Uniprot ID: Q9UIV1 Reactivity: Human, Mouse, Rat Tested Application: ELISA, WB, IP Recommended dilution: WB: 1: 500-1: 2000; IP: 1: 200-1: 2000 Gene ID: 29883 Research Area: Signal Transduction, Metabolism