CNOT3 antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem(ES) cell identity. Immunogen: CCR4-NOT transcription complex, subunit 3 Synonyms: KIAA0691, LENG2, NOT3 Observed MW: 120 kDa Uniprot ID: O75175 Reactivity: Human, Mouse, Rat Tested Application: ELISA, WB, IF, IP Recommended dilution: WB: 1: 500-1: 2000; IP: 1: 200-1: 1000; IF: 1: 20-1: 200 Gene ID: 4849 Research Area: Cardiovascular, Metabolism