CNDP2 antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly(PubMed: 19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase(MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation(PubMed: 24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma(HCC) cells(PubMed: 17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis(PubMed: 25964343). Immunogen: CNDP dipeptidase 2(metallopeptidase M20 family) Synonyms: CN2, CPGL, HEL-S-13, PEPA Observed MW: 54 kDa Uniprot ID: Q96KP4 Reactivity: Human, Mouse, Rat Tested Application: ELISA, WB, IF Recommended dilution: WB: 1: 500-1: 2000; IF: 1: 20-1: 200 Gene ID: 55748 Research Area: Cardiovascular, Metabolism