CHAF1A antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci(By similarity). Immunogen: chromatin assembly factor 1, subunit A(p150) Synonyms: CAF, CAF1P150 Observed MW: 150 kDa Uniprot ID: Q13111 Reactivity: Human, Mouse Tested Application: ELISA, IHC, WB, IP, IF Recommended dilution: WB: 1: 1000-1: 4000; IP: 1: 500-1: 2000; IHC: 1: 20-1: 200; IF: 1: 50-1: 500 Gene ID: 10036 Research Area: Metabolism