CEP290 antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Studies in the Chlamydomonas model system has shown that the ciliary protein CEP290 is a critical component of these Y-link junctions. Additionally, numerous studies have demonstrated that CEP290’s function is critical for IFT—in CEP290 knockdown experiments, many proteins that would normally localize to the cilium fail to do so, and cilium formation is disrupted or absent. Mutations in CEP290 are accountable for cases of nephronophthisis, Leber congenital amaurosis and Joubert syndrome. In IF analtsis of HeLa cells, the white arrows show centrosome and cilium staining. Immunogen: centrosomal protein 290kDa Synonyms: BBS14, KIAA0373, NPHP6,LCA10, MKS4, Nephrocystin 6, rd16, SLSN6, Tumor antigen se2 2 Observed MW: 290 kDa, 150-180 kDa, 80 kDa, 60 kDa Uniprot ID: O15078 Reactivity: Human, Mouse, Rat Tested Application: ELISA, WB, IP, IHC, IF Recommended dilution: WB: 1: 200-1: 2000; IP: 1: 500-1: 5000; IHC: 1: 20-1: 200; IF: 1: 50-1: 500 Gene ID: 80184 Research Area: Cell Division, Proliferation, cancer