CDK5RAP3 antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation(PubMed: 12054757, PubMed: 12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation(PubMed: 17785205, PubMed: 20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint(PubMed: 15790566, PubMed: 19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation(PubMed: 16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress(PubMed: 23152784). May also play a role in the rupture of the nuclear envelope during apoptosis(PubMed: 23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1(PubMed: 21283629). (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry. Immunogen: CDK5 regulatory subunit associated protein 3 Synonyms: IC53, Observed MW: 65 kDa Uniprot ID: Q96JB5 Reactivity: Human, Mouse, Rat Tested Application: ELISA, WB, IHC, IF, FC Recommended dilution: WB: 1: 500-1: 2000; IHC: 1: 20-1: 200; IF: 1: 20-1: 200 Gene ID: 80279 Research Area: Cell Division and Proliferation