CD79A antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex(BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro-and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells. Immunogen: CD79a molecule, immunoglobulin-associated alpha Synonyms: CD79A, Ig alpha, IGA, MB 1, MB 1 membrane glycoprotein, MB1, Surface IgM associated protein Observed MW: 40 kDa Uniprot ID: P11912 Reactivity: Human Tested Application: ELISA, WB, IHC Recommended dilution: WB: 1: 500-1: 2000; IHC: 1: 20-1: 200 Gene ID: 973 Research Area: Cancer, Immunology, Signal Transduction