CD46 antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. Acts as a receptor for adenovirus subgroup B2 and Ad3, cultured measles virus and herpesvirus 6(PubMed: 10972291, PubMed: 12663806, PubMed: 12724329, PubMed: 12915534, PubMed: 14566335, PubMed: 15047806, PubMed: 15078926, PubMed: 15919905, PubMed: 16254377). May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes(PubMed: 7708671, PubMed: 9379894, PubMed: 11260136, PubMed: 11971006). Immunogen: CD46 molecule, complement regulatory protein Synonyms: MCP, MIC10 Observed MW: 50-56 kDa Uniprot ID: P15529 Reactivity: Human, Mouse Tested Application: ELISA, WB, IP Recommended dilution: WB: 1: 500-1: 1000; IP: 1: 200-1: 1000 Gene ID: 4179 Research Area: Immunology, Metabolism