CD33 antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia(in vitro). Immunogen: CD33 molecule Synonyms: SIGLEC3 Observed MW: 67 kDa Uniprot ID: P20138 Reactivity: Human Tested Application: ELISA, WB, IHC, IF Recommended dilution: WB: 1: 500-1: 2000; IHC: 1: 20-1: 200; IF: 1: 20-1: 200 Gene ID: 945 Research Area: Neuroscience, Stem Cells, Immunology, Signal Transduction