CBFA2T3 antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes(PubMed: 12559562, PubMed: 15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner(PubMed: 23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway(PubMed: 25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A(PubMed: 23840896, PubMed: 25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes(By similarity). Plays a role in granulocyte differentiation(PubMed: 15231665). Isoform 2 functions as an A-kinase-anchoring protein(PubMed: 11823486). Immunogen: core-binding factor, runt domain, alpha subunit 2; translocated to, 3 Synonyms: MTG16, MTGR2, ZMYND4 Observed MW: 62-65kd Uniprot ID: O75081 Reactivity: Human, Mouse, Rat Tested Application: ELISA, WB Recommended dilution: WB: 1: 500-1: 2000 Gene ID: 863 Research Area: Metabolism