CAD antibody
Volume: 100 µg
Purification: Immunogen affinity purified
Form: liquid
Purity: 95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID:
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)
Background: The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.
Immunogen: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms:
Observed MW: 243 kDa
Uniprot ID: P27708
Reactivity: Human
Tested Application: ELISA, WB, IHC
Recommended dilution: WB: 1: 500 - 1: 2000; IHC: 1: 50 - 1: 100
Gene ID: 790
Research Area: Metabolism
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Internal Reference:
FNab01183
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