alpha-synuclein antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.) Background: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. Immunogen: synuclein, alpha (non A4 component of amyloid precursor) Synonyms: Alpha synuclein, NACP, PARK1, PARK4, SNCA Observed MW: 15 kDa Uniprot ID: P37840 Reactivity: Human, Rat Tested Application: ELISA, IHC, WB, IF Recommended dilution: WB: 1: 500 - 1: 2000; IHC: 1: 50 - 1: 200; IF: 1: 50 - 1: 200 Gene ID: 6622 Research Area: Neuroscience