ALKBH5 antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine(m6A) RNA, the most prevalent internal modification of messenger RNA(mRNA) in higher eukaryotes(PubMed: 23177736, PubMed: 24778178, PubMed: 24616105, PubMed: 24489119). Can also demethylate N(6)-methyladenosine in single-stranded DNA(in vitro)(PubMed: 24616105). Requires molecular oxygen, alpha-ketoglutarate and iron(PubMed: 21264265, PubMed: 23177736, PubMed: 24778178, PubMed: 24616105, PubMed: 24489119). Demethylation of m6A mRNA affects mRNA processing and export(PubMed: 23177736). Required for spermatogenesis(By similarity). Immunogen: alkB, alkylation repair homolog 5(E. coli) Synonyms: ABH5, ALKBH5, FLJ20308, OFOXD, OFOXD1 Observed MW: 51 kDa Uniprot ID: Q6P6C2 Reactivity: Human, Mouse, Rat Tested Application: ELISA, WB Recommended dilution: WB: 1: 200-1: 1000 Gene ID: 54890 Research Area: Metabolism