ACK1 antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: TNK2, also named as ACK1, belongs to the protein kinase superfamily and Tyr protein kinase family. It is a non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. TNK2 transduces extracellular signals to cytosolic and nuclear effectors. It is a downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. TNK2 confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. The 60-70kd band is the isoform 2 of TNK2. Isoform 1 and 3 is about 120-125kd. Immunogen: tyrosine kinase, non-receptor, 2 Synonyms: TNK2, ACK1, ACK, FLJ45547, ACK 1 Observed MW: 70 kDa Uniprot ID: Q07912 Reactivity: Human, Mouse, Rat Tested Application: ELISA, WB, IHC Recommended dilution: WB: 1: 200-1: 2000; IHC: 1: 20-1: 200 Gene ID: 10188 Research Area: Signal Transduction, Metabolism