ACAA2 Antibody

Size : 50 µL Clone Number: 12F4 Aliases: 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1), ACAA2 Product Type: Recombinant Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P42765 Immunogen: A synthesized peptide derived from human ACAA2 Host: Reactivity: Human, Mouse Tested Applications: ELISA, WB, IHC, IF; Recommended dilution: WB: 1: 500-1: 2000, IHC: 1: 50-1: 200, IF: 1: 50-1: 200 Background: In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed: 25478839). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (PubMed: 18371312). {ECO: 0000269|PubMed: 18371312, ECO: 0000269|PubMed: 25478839, ECO: 0000305|PubMed: 25478839}. Clonality: Monoclonal Isotype: Rabbit IgG Purification Method: Affinity-chromatography Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: ACAA2 Research Areas: Cardiovascular; Tags & Cell Markers; Metabolism; Signal transduction