CRTC3 Antibody

Size : 50 µL Clone Number: 10G3 Aliases: CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3), CRTC3, TORC3 Product Type: Recombinant Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q6UUV7 Immunogen: A synthesized peptide derived from human CRTC3 Host: Reactivity: Human Tested Applications: ELISA, IHC; Recommended dilution: IHC: 1: 50-1: 200 Background: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO: 0000269|PubMed: 14506290, ECO: 0000269|PubMed: 15454081, ECO: 0000269|PubMed: 15466468, ECO: 0000269|PubMed: 16817901, ECO: 0000269|PubMed: 16980408, ECO: 0000269|PubMed: 17210223, ECO: 0000269|PubMed: 17644518}. Clonality: Monoclonal Isotype: Rabbit IgG Purification Method: Affinity-chromatography Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CRTC3 Research Areas: Epigenetics and Nuclear Signaling; Microbiology