CBX2 Antibody

Size : 50 µL Clone Number: 24A2 Aliases: Chromobox protein homolog 2, CBX2 Product Type: Recombinant Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q14781 Immunogen: A synthesized peptide derived from human CBX2 Host: Reactivity: Human, Rat Tested Applications: ELISA, WB; Recommended dilution: WB: 1: 500-1: 2000 Background: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed: 21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed: 21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed: 19361780). {ECO: 0000250|UniProtKB: P30658, ECO: 0000269|PubMed: 19361780, ECO: 0000269|PubMed: 21282530}. Clonality: Monoclonal Isotype: Rabbit IgG Purification Method: Affinity-chromatography Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CBX2 Research Areas: Epigenetics and Nuclear Signaling