COPS3 Antibody

Size : 50 µL Clone Number: 3F9 Aliases: COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3), COPS3, CSN3 Product Type: Recombinant Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q9UNS2 Immunogen: A synthesized peptide derived from human COPS3 Host: Reactivity: Human Tested Applications: ELISA, WB, IHC, IF, FC; Recommended dilution: WB: 1: 500-1: 2000, IHC: 1: 50-1: 200, IF: 1: 50-1: 200, FC: 1: 50-1: 200 Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO: 0000269|PubMed: 11285227, ECO: 0000269|PubMed: 11337588, ECO: 0000269|PubMed: 12628923, ECO: 0000269|PubMed: 12732143, ECO: 0000269|PubMed: 9535219}. Clonality: Monoclonal Isotype: Rabbit IgG Purification Method: Affinity-chromatography Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: COPS3 Research Areas: Neuroscience; Cell biology