CBX5 (Ab-92) Antibody

Size : 100 µL Clone Number: Aliases: Antigen p25 antibody; CBX5 antibody; CBX5_HUMAN antibody; CG8409 antibody; Chromobox 5 antibody; Chromobox homolog 5 (HP1 alpha homolog; Drosophila) antibody; Chromobox homolog 5 antibody; Chromobox protein homolog 5 antibody; Epididymis luminal protein 25 antibody; HEL25 antibody; Heterochromatin protein 1 alpha antibody; Heterochromatin protein 1 antibody; Heterochromatin protein 1 homolog alpha antibody; HP1 alpha antibody; HP1 alpha homolog antibody; HP1 antibody; HP1A antibody; HP1Hs alpha antibody; Su(var)205 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P45973 Immunogen: Synthesized non-phosphopeptide derived from Human HP1 alpha around the phosphorylation site of serine 92 (R-K-S(p)-N-F). Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB, IHC; WB: 1: 500-1: 3000, IHC: 1: 50-1: 100 Background: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Saunders W.S., J. Cell Sci. 104: 573-582(1993). The MGC Project Team; Genome Res. 14: 2121-2127(2004). Ye Q., J. Biol. Chem. 271: 14653-14656(1996). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CBX5 Research Areas: Epigenetics and Nuclear Signaling;Tags & Cell Markers