AATF Antibody

Size : 100 µL Clone Number: Aliases: AATF antibody; AATF_HUMAN antibody; Apoptosis antagonizing transcription factor antibody; Apoptosis-antagonizing transcription factor antibody; BFR2 antibody; CHE 1 antibody; CHE1 antibody; DED antibody; Protein AATF antibody; Rb binding protein Che 1 antibody; Rb-binding protein Che-1 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q9NY61 Immunogen: Synthesized peptide derived from N-terminal of Human AATF. Host: Rabbit Reactivity: Human, Mouse, Rat Tested Applications: ELISA, WB; WB: 1: 500-1: 3000 Background: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. Lindfors K., Biochem. Biophys. Res. Commun. 276: 660-666(2000). Fanciulli M., FASEB J. 14: 904-912(2000). Di Padova M., J. Biol. Chem. 278: 36496-36504(2003). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: AATF Research Areas: Epigenetics and Nuclear Signaling;Cell biology