CNOT2 (Ab-101) Antibody

Size : 100 µL Clone Number: Aliases: CCR4 associated factor 2 antibody; CCR4 NOT transcription complex subunit 2 antibody; CCR4-associated factor 2 antibody; CCR4-NOT transcription complex subunit 2 antibody; CDC36 antibody; CNOT2 antibody; CNOT2_HUMAN antibody; HSPC131 antibody; MSTP046 antibody; Negative regulator of transcription 2 antibody; NOT2 (negative regulator of transcription 2 yeast) homolog antibody; NOT2 antibody; NOT2H antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q9NZN8 Immunogen: Synthesized non-phosphopeptide derived from Human CNOT2 around the phosphorylation site of serine 101 (S-L-S(p)-Q-G). Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB; WB: 1: 500-1: 3000 Background: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity. Albert T.K., Nucleic Acids Res. 28: 809-817(2000). Zhang Q.-H., Genome Res. 10: 1546-1560(2000). Ota T., Nat. Genet. 36: 40-45(2004). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CNOT2 Research Areas: Others