CCNE1 Antibody

Size : 50 µL Clone Number: Aliases: CCNE antibody; Ccne1 antibody; CCNE1_HUMAN antibody; cyclin E variant ex5del antibody; cyclin E variant ex7del antibody; Cyclin E1 antibody; Cyclin Es antibody; Cyclin Et antibody; CyclinE antibody; G1/S specific cyclin E antibody; G1/S-specific cyclin-E1 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P24864 Immunogen: Synthetic peptide of Human CCNE1 Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC; ELISA: 1: 500-1: 5000, IHC: 1: 5-1: 20 Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen affinity purification Conjugate: Non-conjugated Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CCNE1 Research Areas: Epigenetics and Nuclear Signaling;Cancer;Cell biology