CBLN1 Antibody

Size : 100 µL Clone Number: Aliases: [des-Ser1]-cerebellin antibody; CBLN 1 antibody; CBLN1 antibody; CBLN1_HUMAN antibody; CER antibody; Cerebellin 1 antibody; Cerebellin 1 precursor antibody; Cerebellin1 antibody; Precerebellin antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P23435 Immunogen: Synthesized peptide derived from internal of Human CBLN1. Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB; WB: 1: 500-1: 3000 Background: Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion By similarity.The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release By similarity. Urade Y., Proc. Natl. Acad. Sci. U.S.A. 88: 1069-1073(1991). Ota T., Nat. Genet. 36: 40-45(2004). Mural R.J., Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CBLN1 Research Areas: Neuroscience