CDC42BPB Antibody

Size : 100 µL Clone Number: Aliases: CDC42 binding protein kinase beta antibody; CDC42-binding protein kinase beta antibody; CDC42BPB antibody; DMPK like beta antibody; DMPK-like beta antibody; KIAA1124 antibody; MRCK beta antibody; MRCKB_HUMAN antibody; Myotonic dystrophy kinase related CDC42 binding kinase beta antibody; Myotonic dystrophy kinase-related CDC42-binding kinase beta antibody; Myotonic dystrophy protein kinase like beta antibody; Myotonic dystrophy protein kinase-like beta antibody; Serine/threonine protein kinase MRCK beta antibody; Serine/threonine-protein kinase MRCK beta antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q9Y5S2 Immunogen: Synthesized peptide derived from internal of Human MRCKB. Host: Rabbit Reactivity: Human, Mouse, Rat Tested Applications: ELISA, WB, IHC; WB: 1: 500-1: 3000, IHC: 1: 50-1: 100 Background: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. Nakajima D., DNA Res. 9: 99-106(2002). Olsen J.V., Cell 127: 635-648(2006). Hirosawa M., DNA Res. 6: 329-336(1999). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CDC42BPB Research Areas: Signal transduction