CDK5R1 Antibody

Size : 100 µL Clone Number: Aliases: CD5R1_HUMAN antibody; CDK5 activator 1 antibody; CDK5P35 antibody; CDK5R antibody; CDK5R1 antibody; Cyclin dependent kinase 5 regulatory subunit 1 antibody; Cyclin-dependent kinase 5 activator 1 antibody; Cyclin-dependent kinase 5 regulatory subunit 1 antibody; NCK 5A antibody; Neuronal CDK5 activator antibody; p23 antibody; p25 antibody; p35 antibody; Regulatory partner for CDK5 kinase antibody; Tau protein kinase II 23 kDa subunit antibody; TPKII regulatory subunit antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q15078 Immunogen: Synthesized peptide derived from internal of Human CDK5R1. Host: Rabbit Reactivity: Human, Mouse, Rat Tested Applications: ELISA, WB, IF; WB: 1: 500-1: 3000, IF: 1: 100-1: 500 Background: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. Tsai L.-H., Nature 371: 419-423(1994). Patrick G.N., Nature 402: 615-622(1999). Kesavapany S., J. Neurosci. 24: 4421-4431(2004). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CDK5R1 Research Areas: Epigenetics and Nuclear Signaling?Neuroscience;Cell biology;Signal transduction