CCND2 (Ab-280) Antibody

Size : 100 µL Clone Number: Aliases: CCND 2 antibody; ccnd2 antibody; CCND2_HUMAN antibody; CyclinD2 antibody; G1/S specific cyclin D2 antibody; G1/S-specific cyclin-D2 antibody; KIAK0002 antibody; MGC102758 antibody; MPPH3 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P30279 Immunogen: Synthesized non-phosphopeptide derived from Human Cyclin D2 around the phosphorylation site of threonine 280 (A-S-T(p)-P-T). Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB; WB: 1: 500-1: 3000 Background: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity. Xiong Y., Genomics 13: 575-584(1992). Palmero I., Oncogene 8: 1049-1054(1993). Kalnine N., Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CCND2 Research Areas: Epigenetics and Nuclear Signaling;Cancer;Cell biology