DAB1 (Ab-232) Antibody

Size : 100 µL Clone Number: Aliases: Dab 1 antibody; Dab reelin signal transducer 1 antibody; Dab; reelin signal transducer; homolog 1 (Drosophila) antibody; Dab1 antibody; DAB1_HUMAN antibody; Disabled homolog 1 antibody; Disabled homolog 1 Drosophila antibody; Scm antibody; Scr antibody; Scrambler antibody; Yot antibody; Yotari antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: O75553 Immunogen: Peptide sequence around aa.230~234 (G-V-Y-D-V) derived from Human Dab1. Host: Rabbit Reactivity: Human, Mouse, Rat Tested Applications: ELISA, IHC; IHC: 1: 50-1: 100 Background: The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Kelian Chen, et,al. (2003) J. Cell Sci ; 117: 4527 - 4536. Vera Strasser, et,al. (2004) Mol. Cell. Biol ; 24: 1378 - 1386. Izhar Ben-Shlomo, et,al. (2003) Sci. STKE ; 2003: 9. H. M. Kim, et,al. (2002) PNAS ; 99: 4020. Clonality: Polyclonal Isotype: IgG Purification Method: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjugate: Non-conjugated Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: DAB1 Research Areas: Neuroscience;Signal transduction