CCNF Antibody

Size : 100 µL Clone Number: Aliases: Ccnf antibody; CCNF_HUMAN antibody; Cyclin-F antibody; F box only protein 1 antibody; F-box only protein 1 antibody; FBX1 antibody; FBXO1 antibody; G2 mitotic specific cyclin F antibody; G2/mitotic specific cyclin F antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P41002 Immunogen: Synthesized peptide derived from Human Cyclin F. Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB, IHC; WB: 1: 500-1: 3000, IHC: 1: 50-1: 100 Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. Tsz Kan Fung, J. Biol. Chem., Sep 2002; 277: 35140 - 35149. Michael T. Tetzlaff, Mol. Cell. Biol., Mar 2004; 24: 2487 - 2498. Cain H. Yam, Mol. Cell. Biol., Jan 1999; 19: 635 - 645. Michael T. Tetzlaff, PNAS, Mar 2004; 101: 3338 - 3345. Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CCNF Research Areas: Cell biology