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CREBBP Antibody

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Size : 100 µL Clone Number: Aliases: CBP antibody; CBP_HUMAN antibody; CREB binding protein antibody; CREB-binding protein antibody; Crebbp antibody; Cyclic AMP responsive enhancer binding protein antibody; KAT3A antibody; RSTS antibody; RTS antibody; Rubinstein Taybi syndrome antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q92793 Immunogen: Synthesized peptide derived from Human CREB-BP. Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB, IHC, IF; WB: 1: 500-1: 3000, IHC: 1: 50-1: 100, IF: 1: 100-1: 500 Background: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Zoi Lygerou, Nucleic Acids Res., Feb 1994; 22: 5332 - 5340. Karsten Grote, J. Biol. Chem., Dec 2004; 279: 55675 - 55681. Kumi Nagamoto-Combs, J. Biol. Chem., Feb 1997; 272: 6051. Stephen J. Elliman, Isaac, J. Biol. Chem., Jan 2006; 281: 16 -19 Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CREBBP Research Areas: Epigenetics and Nuclear Signaling;Cancer;Metabolism?Microbiology;Stem cells

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Internal Reference: CSB-PA901849

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