FZR1 Antibody

Size : 50 µg Clone Number: Aliases: CDC20 like 1b antibody; CDC20 like protein 1 antibody; CDC20-like protein 1 antibody; CDC20C antibody; CDH1 antibody; Cdh1/Hct1 homolog antibody; Fizzy related protein 1 antibody; Fizzy related protein antibody; Fizzy related protein homolog antibody; Fizzy-related protein homolog antibody; Fizzy/cell division cycle 20 related 1 antibody; FYR antibody; FZR 1 antibody; FZR 2 antibody; Fzr antibody; FZR_HUMAN antibody; Fzr1 antibody; Fzr1 protein antibody; FZR2 antibody; HCDH 1 antibody; HCDH antibody; hCDH1 antibody; KIAA1242 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q9UM11 Immunogen: Recombinant Human Fizzy-related protein homolog protein (1-493AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB, IHC; Recommended dilution: WB: 1: 500-1: 2000, IHC: 1: 20-1: 200 Background: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: Non-conjugated Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: FZR1 Research Areas: Cell biology