CHMP2B Antibody

Size : 50 µL Clone Number: Aliases: ALS17 antibody; Charged multivesicular body protein 2b antibody; CHM2B_HUMAN antibody; CHMP family; member 2B antibody; CHMP2.5 antibody; CHMP2b antibody; Chromatin modifying protein 2b antibody; Chromatin-modifying protein 2b antibody; DMT1 antibody; hVps2-2 antibody; Vacuolar protein sorting 2; yeast; homolog of; B antibody; Vacuolar protein sorting 2-2 antibody; Vacuolar protein sorting-associated protein 2-2 antibody; VPS2 homolog B antibody; Vps2-2 antibody; VPS2B antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q9UQN3 Immunogen: Recombinant Human Charged multivesicular body protein 2b protein (1-213AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC; Recommended dilution: IHC: 1: 20-1: 200 Background: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen Affinity Purified Conjugate: Non-conjugated Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CHMP2B Research Areas: Neuroscience; Signal transduction