DACT1 Antibody, Biotin conjugated

Size : 50 µg Clone Number: Aliases: Dact antibody; dact1 antibody; DACT1_HUMAN antibody; Dapper antagonist of beta catenin homolog 1 antibody; Dapper antagonist of catenin 1 antibody; Dapper antibody; Dapper homolog 1 antibody; DAPPER1 antibody; Dpr antibody; Dpr1 antibody; Frd antibody; Frodo antibody; hDPR1 antibody; Hepatocellular carcinoma novel gene 3 protein antibody; Heptacellular carcinoma novel gene 3 antibody; HNG3 antibody; MTNG3 antibody; Thyex3 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q9NYF0 Immunogen: Recombinant Human Dapper homolog 1 protein (410-525AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA Background: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1: CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines. Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: Biotin Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: DACT1 Research Areas: Neuroscience; Stem cells