Cobra venom factor Antibody

Size : 50 µg Clone Number: Aliases: antibody; Cobra venom factor antibody; CVF antibody; CVFk antibody; Complement C3 homolog) [Cleaved into: Cobra venom factor alpha chain; Cobra venom factor gamma chain; Cobra venom factor beta chain] antibody Product Type: Polyclonal Antibody Immunogen Species: Naja kaouthia UniProt ID: Q91132 Immunogen: Recombinant Naja kaouthia Cobra venom factor protein (733-984AA) Host: Rabbit Reactivity: Naja kaouthia Tested Applications: ELISA, WB; Recommended dilution: WB: 1: 500-1: 5000 Background: Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity. Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: Non-conjugated Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: Research Areas: Others