CHD5 Antibody, HRP conjugated

Size : 50 µg Clone Number: Aliases: ATP-dependent helicase CHD5 antibody; CHD 5 antibody; CHD-5 antibody; CHD5 antibody; CHD5_HUMAN antibody; Chromodomain-helicase-DNA-binding protein 5 antibody; DKFZp434N231 antibody; KIAA0444 antibody; RP1-233K16.2 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q8TDI0 Immunogen: Recombinant Human Chromodomain-helicase-DNA-binding protein 5 protein (1600-1699AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA Background: Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated \'Lys-27\' (H3K27me3) and non-methylated \'Lys-4\' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at \'Lys-27\' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: HRP Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CHD5 Research Areas: Epigenetics and Nuclear Signaling