CDK5RAP2 Antibody, HRP conjugated

Size : 50 µg Clone Number: Aliases: C48 antibody; CDK5 activator-binding protein C48 antibody; CDK5 regulatory subunit associated protein 2 antibody; CDK5 regulatory subunit-associated protein 2 antibody; CDK5RAP2 antibody; centrosomal protein 215 kDa antibody; Centrosome-associated protein 215 antibody; CEP215 antibody; CK5P2_HUMAN antibody; MCPH3 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q96SN8 Immunogen: Recombinant Human CDK5 regulatory subunit-associated protein 2 protein (996-1111AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA Background: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of a gamma-tubulin ring complex onto centrosomes (PubMed: 26485573). Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: HRP Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CDK5RAP2 Research Areas: Epigenetics and Nuclear Signaling; Neuroscience; Cell biology; Tags & Cell Markers; Signal transduction