CRBN Antibody

Size : 50 µL Clone Number: Aliases: 2610203G15Rik antibody; 2900045O07Rik antibody; AF229032 antibody; AW108261 antibody; Cereblon antibody; Crbn antibody; CRBN_HUMAN antibody; DKFZp781K0715 antibody; MGC27358 antibody; MRT2A antibody; OTTHUMP00000209555 antibody; piL antibody; Protein cereblon antibody; Protein x 0001 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q96SW2 Immunogen: Recombinant Human Protein cereblon protein (1-280AA) Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB, IHC; Recommended dilution: WB: 1: 1000-1: 5000, IHC: 1: 20-1: 200 Background: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen Affinity Purified Conjugate: Non-conjugated Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CRBN Research Areas: Neuroscience