CDK5RAP3 Antibody, Biotin conjugated

Size : 50 µL Clone Number: Aliases: C53 antibody; CDK5 activator binding protein C53 antibody; CDK5 activator-binding protein C53 antibody; CDK5 regulatory subunit associated protein 3 antibody; CDK5 regulatory subunit-associated protein 3 antibody; Cdk5rap3 antibody; CK5P3_HUMAN antibody; HSF 27 antibody; HSF27 antibody; IC53 antibody; Ischemic heart CDK5 activator binding protein C53 antibody; LXXLL/leucine zipper containing ARFbinding protein antibody; LZAP antibody; MST016 antibody; OK/SW cl.114 antibody; PP1553 antibody; Protein HSF-27 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q96JB5 Immunogen: Recombinant Human CDK5 regulatory subunit-associated protein 3 protein (42-292AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA Background: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed: 12054757, PubMed: 12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed: 17785205, PubMed: 20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed: 15790566, PubMed: 19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed: 16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed: 23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed: 23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed: 21283629). Clonality: Polyclonal Isotype: IgG Purification Method: Antigen Affinity Purified Conjugate: Biotin Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CDK5RAP3 Research Areas: Cancer; Cell biology; Signal transduction