ALKBH8 Antibody

Size : 50 µL Clone Number: Aliases: 4930562C03Rik antibody; 8030431D03Rik antibody; 9430088N01Rik antibody; ABH8 antibody; alkB alkylation repair homolog 8 (E. coli) antibody; alkB alkylation repair homolog 8 antibody; AlkB homologue 8 antibody; ALKB8_HUMAN antibody; ALKBH8 antibody; Alkylated DNA repair protein alkB homolog 8 antibody; FLJ38204 antibody; MGC10235 antibody; OTTHUMP00000211286 antibody; OTTHUMP00000211287 antibody; Probable alpha-ketoglutarate-dependent dioxygenase ABH8 antibody; RGD1304687 antibody; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8 antibody; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q96BT7 Immunogen: Recombinant Human Alkylated DNA repair protein alkB homolog 8 protein (1-230AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC; Recommended dilution: IHC: 1: 20-1: 200 Background: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed: 20123966, PubMed: 20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed: 20123966, PubMed: 20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed: 20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed: 21285950). Required for normal survival after DNA damage (PubMed: 20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed: 19293182). Clonality: Polyclonal Isotype: IgG Purification Method: Antigen Affinity Purified Conjugate: Non-conjugated Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: ALKBH8 Research Areas: Epigenetics and Nuclear Signaling; Cancer