CTCFL Antibody

Size : 50 µL Clone Number: Aliases: BORIS like protein antibody; Brother of the regulator of imprinted sites antibody; Cancer/testis antigen 27 antibody; CCCTC binding factor (zinc finger protein) like antibody; CCCTC-binding factor antibody; CT27 antibody; CTCF paralog antibody; CTCF T antibody; CTCF-like protein antibody; Ctcfl antibody; CTCFL_HUMAN antibody; dJ579F20.2 antibody; HMG 1L1 antibody; HMGB1L1 antibody; MGC163358 antibody; MGC169105 antibody; MGC169106 antibody; Putative high mobility group protein 1 like 1 antibody; Putative high mobility group protein B1 like 1 antibody; Transcriptional repressor CTCFL antibody; Zinc finger protein CTCF-T antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q8NI51 Immunogen: Recombinant Human Transcriptional repressor CTCFL protein (1-270AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC; Recommended dilution: IHC: 1: 20-1: 200 Background: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 \\\'Arg-3\\\' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen Affinity Purified Conjugate: Non-conjugated Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CTCFL Research Areas: Epigenetics and Nuclear Signaling; Cancer