COMMD1 Antibody

Size : 50 µL Clone Number: Aliases: C2orf5 antibody; COMD1 antibody; COMD1_HUMAN antibody; COMM domain-containing protein 1 antibody; COMMD1 antibody; Copper metabolism (Murr1) domain containing 1 antibody; Copper metabolism domain containing 1 antibody; Copper metabolism gene MURR1 antibody; Copper metabolism MURR1 domain-containing protein 1 antibody; MGC27155 antibody; MURR1 antibody; Protein Murr1 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q8N668 Immunogen: Recombinant Human COMM domain-containing protein 1 protein (1-190AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC; Recommended dilution: IHC: 1: 20-1: 200 Background: Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed: 21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed: 15799966, PubMed: 17183367, PubMed: 20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed: 23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed: 14645214, PubMed: 20237237, PubMed: 21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed: 21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed: 20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed: 25355947). Can bind one copper ion per monomer (PubMed: 17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed: 18940794). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed: 20458141). Clonality: Polyclonal Isotype: IgG Purification Method: Antigen Affinity Purified Conjugate: Non-conjugated Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: COMMD1 Research Areas: Epigenetics and Nuclear Signaling; Cancer; Metabolism; Signal transduction