CATSPER4 Antibody, Biotin conjugated

Size : 50 µg Clone Number: Aliases: CATSPER4Cation channel sperm-associated protein 4 antibody; CatSper4 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q7RTX7 Immunogen: Recombinant Human Cation channel sperm-associated protein 4 protein (306-472AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA Background: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: Biotin Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CATSPER4 Research Areas: Neuroscience