CYP2C8 Antibody

Size : 100 µL Clone Number: Aliases: CP2C8_HUMAN antibody; CPC8 antibody; CYP2C8 antibody; CYPIIC8 antibody; Cytochrome P450 2C8 antibody; Cytochrome P450 family 2 subfamily C polypeptide 8 antibody; Cytochrome P450 form 1 antibody; Cytochrome P450 IIC2 antibody; Cytochrome P450 MP-12 antibody; Cytochrome P450 MP-20 antibody; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 8 antibody; Flavoprotein linked monooxygenase antibody; Microsomal monooxygenase antibody; MP 12/MP 20 antibody; P450 form 1 antibody; P450 IIC2 antibody; P450 MP 12/MP 20 antibody; S mephenytoin 4 hydroxylase antibody; S-mephenytoin 4-hydroxylase antibody; Xenobiotic monooxygenase antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P10632 Immunogen: Synthesized peptide derived from internal of Human Cytochrome P450 2C8. Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB, IHC; WB: 1: 500-1: 3000, IHC: 1: 50-1: 100 Background: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol). Romkes M., Biochemistry 30: 3247-3255(1991). Ged C., Biochim. Biophys. Acta 1088: 433-435(1991). Zeldin D.C., Arch. Biochem. Biophys. 322: 76-86(1995). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CYP2C8 Research Areas: Cancer Cardiovascular;Metabolism;Signal transduction