CDKN2AIP Antibody

Size : 50 µL Clone Number: Aliases: Calcium response factor antibody; CARF antibody; CARF_HUMAN antibody; CDKN2A interacting protein antibody; CDKN2A-interacting protein antibody; Cdkn2aip antibody; collaborates/cooperates with ARF (alternate reading frame) protein antibody; Collaborator of ARF antibody; FLJ20036 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q9NXV6 Immunogen: Fusion protein of Human CDKN2AIP Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC; ELISA: 1: 1000-1: 5000, IHC: 1: 50-1: 200 Background: CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen affinity purification Conjugate: Non-conjugated Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CDKN2AIP Research Areas: Epigenetics and Nuclear Signaling;Cancer;Cell biology