CLDN14 Antibody

Size : 50 µL Clone Number: Aliases: AI851731 antibody; Claudin 14 antibody; Claudin-14 antibody; CLD14_HUMAN antibody; CLDN 14 antibody; CLDN14 antibody; DFNB 29 antibody; DFNB29 antibody; Human CLDN14 gene antibody; MGC109472 antibody; OTTHUMP00000109046 antibody; OTTHUMP00000109049 antibody; OTTMUSP00000021531 antibody; UNQ777/PRO1571 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: O95500 Immunogen: Synthetic peptide of Human CLDN14 Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB; ELISA: 1: 1000-1: 10000, WB: 1: 200-1: 1000 Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen affinity purification Conjugate: Non-conjugated Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CLDN14 Research Areas: Neuroscience;Signal transduction